Lidocaine Freebase | CAS 137-58-6 | Pharmaceutical Grade Anesthetic Base Compound

Comprehensive Chemical Overview

Lidocaine Freebase (CAS 137-58-6) represents the fundamental molecular form of one of the world’s most versatile local anesthetics, providing the chemical foundation for numerous pharmaceutical formulations. For researchers and formulators investigating what is lidocaine at its core, this is the pure, un-ionized base compound that offers distinct advantages in specific applications. Unlike its water-soluble hydrochloride salt counterpart, lidocaine freebase exhibits enhanced lipid solubility, making it particularly valuable for transdermal formulations and specialized delivery systems.

Understanding the lidocaine base vs lidocaine HCl conversion process is crucial for pharmaceutical scientists seeking to optimize drug delivery across various biological membranes.

Elite Technical Specifications

• Chemical Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide

• Synonyms: Lignocaine Base, Lidocaine Base

• CAS Number: 137-58-6

• Molecular Formula: C₁₄H₂₂N₂O

• Molecular Weight: 234.34 g/mol

• Appearance: White to off-white crystalline powder

• Purity: ≥99% (Pharmaceutical Grade, HPLC-verified)

• Solubility: Freely soluble in ethanol, acetone, and chloroform; sparingly soluble in water

• Melting Point: 66-69°C

• Storage: Store in airtight, light-resistant containers at controlled room temperature

Authorized Applications & Uses

Our premium Lidocaine Freebase serves specialized roles in advanced pharmaceutical development:

1. Transdermal Delivery Systems

• Enhanced penetration formulations for topical anesthetics

• Patch technologies requiring lipid-soluble active ingredients

• Dermatological preparations with improved skin permeability

• Cosmetic applications requiring deep tissue penetration

2. Mucosal & Specialized Formulations

• Mucoadhesive delivery systems for oral and genital mucosa

• Liposomal encapsulation for sustained release formulations

• Oil-based preparations where water solubility is undesirable

• Veterinary formulations requiring enhanced tissue penetration

3. Pharmaceutical Research & Development

• Structure-activity relationship studies of local anesthetics

• Drug delivery optimization for enhanced bioavailability

• Alternative formulation development for patients with allergy to lidocaine hydrochloride

• Comparative studies of different salt forms and their pharmacokinetics

Pharmacological & Chemical Profile

Understanding Lidocaine’s Fundamental Properties:

Mechanism of Action:

• How lidocaine works: Potent voltage-gated sodium channel blockade

• Mechanism of action of lidocaine: Prevents neuronal depolarization and action potential propagation

• Local anesthetic onset of action: Rapid penetration through lipid membranes

Chemical Properties:

• Lidocaine base offers superior lipid solubility compared to hydrochloride salt

• Why is lidocaine hydrochloride used instead of lidocaine: Better water solubility for injectable formulations

• Is lidocaine water soluble: The freebase form has limited water solubility

Comparative Advantages:

• Enhanced penetration through lipid-rich biological barriers

• Ideal for formulations where water content must be minimized

• Preferred for certain transdermal and mucosal delivery systems

⚠️ Critical Safety & Handling Information

WARNING: LIDOCAINE FREEBASE IS A POTENT PHARMACEUTICAL COMPOUND WITH CARDIAC AND NEUROLOGICAL EFFECTS AT HIGH DOSES. Proper handling and professional use are mandatory.

Safety Considerations:

• Lidocaine side effects may include CNS and cardiovascular toxicity

• Allergy to lidocaine is rare but possible; appropriate testing recommended

• Alternative to lidocaine may be required for sensitive patients

• Professional formulation required before any medical application

Handling Protocols:

• Use appropriate PPE: nitrile gloves, lab coat, and safety goggles

• Handle in controlled pharmaceutical environments only

• Implement engineering controls for powder handling

• Follow strict quality control measures for formulation work

Order Now – For Qualified Professionals Only

Secure Your Pharmaceutical-Grade Anesthetic Base
Advance your formulation capabilities with our certified Lidocaine Freebase.

PHARMACEUTICAL GRADE QUALITY:

• Batch-specific Certificate of Analysis

• HPLC purity verification ≥99%

• Comprehensive documentation package

• cGMP-compliant manufacturing standards

Every Order Includes:

• Certificate of Analysis (CoA) with comprehensive testing data

• Material Safety Data Sheet (MSDS)

• Regulatory Compliance Documentation

• Technical Support Documentation

• Secure, Pharmaceutical-Grade Packaging

⚖️ Legal Disclaimer

This product, Lidocaine Freebase (CAS 137-58-6), is sold strictly as a chemical intermediate for pharmaceutical research, development, and compounding applications by qualified professionals. It is NOT for human or veterinary use in its raw form. The buyer is 100% responsible for ensuring compliance with all local, state, and federal regulations regarding the purchase, handling, and use of this material. Proof of professional credentials and intended legitimate use may be required.